Clinical , Morphological , and Cell Kinetic Differences Among Multiple Myeloma , Monoclonal Gammopathy of Undetermined Significance , and Smoldering Multiple Myeloma
نویسنده
چکیده
We reviewed the clinical and morphological findings in 43 cases of monoclonal gammopathy of undetermined significance (MGUS). 9 of smoldering multiple myeloma (5MM). and 23 of overt multiple myeloma (MM). In all cases. the patients physicians had requested a bone marrow examination because of the possibility of MM. In all 75 cases. 3H-thymidine labeling indices were performed. The plasma cell labeling index correctly classified 62 of the 75 cases (83%). A linear discriminant function combining the labeling index and percentage of plasma cells improved the accuracy to 92% (69/75). or to 95% (71 /75) if patients in whom MM developed within 6 mo were considered to have
منابع مشابه
Clinical , Morphological , and Cell Kinetic Differences Among Multiple Myeloma , Monoclonal Gammopathy of Undetermined
We reviewed the clinical and morphological findings in 43 cases of monoclonal gammopathy of undetermined significance (MGUS). 9 of smoldering multiple myeloma (5MM). and 23 of overt multiple myeloma (MM). In all cases. the patients physicians had requested a bone marrow examination because of the possibility of MM. In all 75 cases. 3H-thymidine labeling indices were performed. The plasma cell l...
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A multistep model has been proposed of disease progression starting in monoclonal gammopathy of undetermined significance continuing through multiple myeloma, sometimes with an intermediate entity called smoldering myeloma, and ending in extramedullary disease. To gain further insights into the role of the transcriptome deregulation in the transition from a normal plasma cell to a clonal plasma...
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BACKGROUND Multiple myeloma, monoclonal gammopathy of undetermined significance and smoldering multiple myeloma harbor common chromosomal abnormalities but the prevalence and relative association of aberrations in these diagnostic groups remains controversial. We investigated these aspects in a large series of patients. DESIGN AND METHODS Chromosome 13 deletion (Delta13), deletion of TP53, pl...
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Dicer and Drosha are key enzymes in the miRNA-processing pathway which is altered in many human cancers. We analyzed Dicer and Drosha expression levels by quantitative PCR in 151 patients with monoclonal gammopathies: 102 symptomatic myeloma patients, 23 smoldering myelomas and 26 monoclonal gammopathy of undetermined significance. We found that Dicer expression values were significantly higher...
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